- Baer Family Papers, 1744/19291
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Bakers' Guild Bylaws and Register (Harburg, Germany), 1668/18091
- Barron Family Papers, 1793/19421
- Barry S. Martin collection of historical manuscripts and documents, 1771/18304
- Baylor Family Papers
1653-19157
- Benjamin Kissam papers, 1755/17762
- Benjamin Layman Papers, 1752/18152
- Benjamin Owen Tyler calligraphic manuscript and Fenno family papers, 1770/18161
- Berkeley Family Papers
1536-present1
- Bevill Family Papers, 1558/1939, bulk 1558/17071
- Bigler-Sessler-John Family Papers, 1752/19251
- Bishop James Madison Collection, 1776/18071
- Bishop James Madison's preparatory notes on Smith's Wealth of Nations, 1776/18122
- Blair Family Papers, 1741/17921