- Alexander Balmaine Memorandum Book, 1775/18201
- Andrew Lindamood papers, 1768/18171
- Austin-Twyman Papers, 1765/19395
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Benjamin Layman Papers, 1752/18151
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18171
- Blow Family Papers, 1613/1960, bulk 1770/187518
- Board of Visitors records, 1757/20232
- Brafferton Estate Collection, 1691/19351
- Brainard Charlton Collection of Colonial and Continental Paper Money, 1775/17801
- Bray Papers, 1730/18173
- C. L. Worthington Papers, 1752/19382
- Cabell Family Papers, 1693/1913, bulk 1743/18233
- Campbell Family Papers, 1726/19203
- Carter Family Papers, 1667/1862, bulk 1792/18612