- Land Grants, 1749/19851
- Latane Family Papers
1650-189811
- Latin American Map Collection, 1711/18731
- Lee Nicholson Papers, 1827/19387
- Lee-Jackson Foundation collection, 1744/19081
- Legal Documents, 1742/18952
- Lester J. Cappon Papers, 1809/19812
- Lexington Arsenal and Virginia Militia records, 1702/18393
- Logan Osborne Family and Business Records, 1761/19821
- Long/Trail Southeastern West Virginia Historical Records, 1870/20251
- Lonnie L. Okes, Compiler, Akers, Lilly, and Ellison Families History, 1700/19611
- Louis-Jacques Gossier drawing for the Encyclopédie, 1760/17691
- Lucy Lee Lancaster Papers, 1915/19891
- Lyman C. Draper, Antiquarian, Manuscripts, 1740/18151
- Lynch Family History, 1600/19401