- Charles Campbell Papers, 1743/18967
- Chester McNerney Collection, 1290/19501
- Clara L. Lawrence Papers, 1763/19393
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18392
- Commission of Francis Lightfoot Lee et al. as Justices of the Peace from His Majesty's Lt. Governor, Francis Fauqier, 17672
- Commissions of the Peace for Sussex County, Virginia, 1754/17711
- Dismal Swamp Collection, 1763/19281
- Dunmore Family Papers (I) [in part photocopies], 1650/18992
- Earl Gregg Swem Genealogy Collection, 1719/19825
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190097
- Eliza H. Cocke Scrapbook, 1754/1823, bulk 18232
- English Autographs and Signatures Collection, 1710/19151
- Ephemera Collection, 1800/20141