- Armistead-Cocke Papers, 1680/19172
- Austin-Twyman Papers, 1765/19392
- Barron Family Papers, 1793/19421
- Barry S. Martin collection of historical manuscripts and documents, 1771/18301
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Board of Visitors records, 1757/20232
- Cabell Family Papers, 1693/1913, bulk 1743/18232
- Carl R. Dolmetsch Papers, 1751/19901
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles Brown Papers, 1792/18881
- Charles Campbell Papers, 1743/18963
- Clara L. Lawrence Papers, 1763/19391
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Faculty Assembly Records, 1729/20081
- Galt Papers (I), 1745/18923