- Colvin Papers, 1734/18392
- Commissions of the Peace for Sussex County, Virginia, 1754/17712
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18871
- Dickson Family Papers, 1769/19241
- Doddridge Family Manuscript, 1745/18571
- Donovan H. Bond, Compiler, Research Papers regarding Vandalia Colony and West Virginia Forts, 1962/2002, bulk 1756/19951
- Dunmore Family Papers (I) [in part photocopies], 1650/18992
- Earl Gregg Swem Genealogy Collection, 1719/19825
- Earl L. Core (1902-1984) Papers, 1756/19853
- Edgar E. MacDonald papers, 1933/19931
- Edward Vitale violin music collection, 1700/19001
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199518
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Eliza H. Cocke Scrapbook, 1754/1823, bulk 18232