- Land Grants, 1749/19851
- Latane Family Papers
1650-189810
- Latin American Map Collection, 1711/18731
- Lee Nicholson Papers, 1827/19387
- Lee-Jackson Foundation collection, 1744/19081
- Legal Documents, 1742/18952
- Letters from John Caygill to Josias Clapham regarding cargo shipments, 1751/17541
- Lexington Arsenal and Virginia Militia records, 1702/18393
- Livre pour la remede pour les chevaux [Book of the remedy for horses], 1741/17601
- Long/Trail Southeastern West Virginia Historical Records, 1870/20251
- Lonnie L. Okes, Compiler, Akers, Lilly, and Ellison Families History, 1700/19611
- Lyman C. Draper, Antiquarian, Manuscripts, 1740/18151
- Lynch Family History, 1600/19401