- Jan Karon papers, 1918/2018, bulk 1964/20181
- John Gottfried Watenbach calligraphic sample book, 1748/17721
- John W. Warner papers, 1967/2009, bulk 1967/20081
- Joseph C. Cabell and the Cabell Family papers
1731-19171
- Latane Family Papers
1650-189810
- Livre pour la remede pour les chevaux [Book of the remedy for horses], 1741/17601
- Miscellaneous Oversize collection, 1944/20071
- Morris Family Papers
1727-19311
- Nourse Family Papers
1751-19181
- Nourse Family Papers
1760-18381
- Ollen Lawrence Burnette, Jr. papers, 1815/20141
- Papers of Mary Johnston1
- Papers of the Low Moor Iron Company
1873-19271
- Papers of the Preston and Related Radford Families, 1744-18953
- Papers of the Randolph Family of Edgehill, 1732/18603