- W. Jett Lauck papers, 1900/19522
- Wade Hampton Frost papers, 1880/19844
- Waller family papers, 1677/19652
- Walter Jones Papers, 1721/17672
- Washington and Lee University and Regional Virginia History Research Collection, 1609/20163
- Watts family papers-addition, 1786/19501
- Webb-Prentis Family Papers
1770-19082
- Webb-Prentis Family Papers,
1735-19423
- West Virginia Land Grants Records, 1748/19123
- West Virginia Naturalization Records, 1814/19911
- Wickham family papers, 1704/19503
- William Booth Taliaferro Papers, 1811/19543
- William Cole Collection of Documents Pertaining to the Colonial-Era, 1676/1971, bulk 1730/17701
- William K. Perrin Papers, 1732/1902, bulk 1820/18582
- William Munford Tuck Papers, 1918/19681