- Saint Andrew's Society collection, 1861/19952
- Samuel H. Yonge papers, 1890/19351
- Sheet Music Collection, 1827/19742
- Shenandoah County Historical Society Collection, 1147/20004
- Short Papers, 1675/17891
- Sir Jeffray Gilbert Notes, 1750/18002
- Slaveship "Elizabeth" Records, 17502
- Somerville family papers, 1821/20131
- Southall Papers, 1807/19042
- Stearns Family Papers, 1714/19203
- Steve Wolfe, Collector, Historical Newspapers, 1666/19952
- Surveying Collection, 1741/18012
- Susan H. Godson Papers, 1980/19931