- M.C. Wilhelm Medical History collection, 1959/19761
- Maben Jones Papers2
- Malone Family Genealogy, 1700/19501
- Manley Family papers, 1707/19533
- Manuscript leaves from the Qur'an and Dala'il al-Khayrat, 1700/19001
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19492
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Manuscripts Artifact Collection, 1800/20101
- Map Collection, 1629/19913
- Margaret Forbes Brand, Compiler, Genealogies, 1500/19651
- Margaret Grattan Weaver collection, 1707/1992, bulk 1857/19102
- Marshall W. Fishwick Collection, 1700/2007, bulk 1923/20072
- Mary and Hannah Gibbons Papers, 1743/18902
- Mason C. Andrews Papers, 1777/2010, bulk 1950/19901
- Maupin-Washington Papers, 1732/19323