- Earl Gregg Swem Genealogy Collection, 1719/19822
- Edgar E. MacDonald papers, 1933/19931
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199517
- Emory L. Kemp Papers regarding Industrial History, 1735/20212
- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19821
- Ethelyn Cox Collection (MS287), 1956/19801
- Fairfax Harrison Papers, 1736/19456
- Galt Papers (III), 1750/19911
- George Mason Papers, 1706/18581
- George Mason University Student Government records, 1968/20191
- Governor Arch A. Moore Jr. papers, 1950/19891
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- Hill Family Genealogy, 1700/1999, bulk 1980/199910