- Bushrod Washington family papers, 1662/18351
- Byer Family Genealogy, 1726/19381
- C. Harrison Mann, Jr. Map Collection, 1579/19611
- C. Harrison Mann, Jr. map collection, 1579/19611
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1726/19201
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles A. Miller Family Papers, 1708/19261
- Charles Campbell Papers, 1743/18961
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Charles and Thomas Frankland record books, 1740/18111
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/19451
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581