- A. E. Dick Howard papers, 1928/20171
- Advisory Committee Research Collection, 1772/20171
- Austin-Twyman Papers, 1765/19391
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Blow Family Papers, 1613/1960, bulk 1770/18753
- Board of Visitors records, 1757/20231
- Bray Papers, 1730/18172
- C. L. Worthington Papers, 1752/19381
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1726/19201
- Carter Family Papers, 1667/1862, bulk 1792/18612
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Charles Campbell Papers, 1743/18961
- Christian S. Hutter miscellany, 1602/19458
- Colvin Papers, 1734/18391