- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18872
- Dickson Family Papers, 1769/19241
- Dunmore Family Papers (I) [in part photocopies], 1650/18993
- Earl Gregg Swem Genealogy Collection, 1719/19825
- Edgar E. MacDonald papers, 1933/19931
- Edward Vitale violin music collection, 1700/19001
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199517
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Elizabeth Fairfax cookbook, 1694/17953
- Emory L. Kemp Papers regarding Industrial History, 1735/20215
- English Autographs and Signatures Collection, 1710/19151
- English and American legal documents, 1559/18471
- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19821