- Campbell Family Papers, 1726/19203
- Carol R. Lubin papers, 1960/19812
- Carter Family Papers, 1667/1862, bulk 1792/186117
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Charles A. Miller Family Papers, 1708/19261
- Charles Campbell Papers, 1743/18964
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Charles and Thomas Frankland record books, 1740/18112
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/19459
- Cocke Family Papers,
1725-19391
- Cocke and Related Family Papers,
ca.1773-19921
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18392