- Elise S. Billmyer, Collector, Papers, 1636/19611
- Elizabeth Fairfax cookbook, 1694/17953
- Emory L. Kemp Papers regarding Industrial History, 1735/20215
- English Autographs and Signatures Collection, 1710/19151
- English and American legal documents, 1559/18472
- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19821
- European figure engravings, 1535/18491
- Facilities Management Records, 1678/20031
- Faculty Assembly Records, 1729/20083
- Fairfax-Spencer family recipe book, 1694/17951
- Florence Montgomery, Compiler, Monongalia and Tyler Counties Genealogies, 1700/19501
- Fowler Family Papers, 1700/1943, bulk 1830/18601
- Francis P. Lee Papers, 1727/19301
- Genealogical Society of Southwestern Pennsylvania, Collector, Material regarding Monongalia County Unrecorded Wills, 1726/17811