- Charles A. Miller Family Papers, 1708/19261
- Charles Campbell Papers, 1743/18961
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/19459
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18392
- Cyril Wyche receipts from booksellers, 1706/17361
- Dunmore Family Papers (I) [in part photocopies], 1650/18992
- Earl Gregg Swem Genealogy Collection, 1719/19823
- Edgar E. MacDonald papers, 1933/19931
- Edward Vitale violin music collection, 1700/19001
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199515