- Campbell Family Papers, 1726/19201
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles A. Miller Family Papers, 1708/19261
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/19451
- Claude Pierre Pecaudy de Contrecoeur Land Transfer, 17301
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Cyril Wyche receipts from booksellers, 1706/17361
- Dunmore Family Papers (I) [in part photocopies], 1650/18991
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Edward Vitale violin music collection, 1700/19001
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Elizabeth Fairfax cookbook, 1694/17951