- C. Harrison Mann, Jr. Map Collection, 1579/19611
- C. Harrison Mann, Jr. map collection, 1579/19611
- Cabell Family Papers, 1693/1913, bulk 1743/18234
- Carol R. Lubin papers, 1960/19812
- Carter Family Papers, 1667/1862, bulk 1792/18619
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Charles A. Miller Family Papers, 1708/19262
- Charles Campbell Papers, 1743/18961
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/19459
- Cocke Family Papers,
1725-19393
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Cyril Wyche receipts from booksellers, 1706/17361