- Edward Vitale violin music collection, 1700/19001
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199513
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Elizabeth Fairfax cookbook, 1694/17953
- English and American legal documents, 1559/18471
- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19821
- European figure engravings, 1535/18491
- Facilities Management Records, 1678/20031
- Fairfax-Spencer family recipe book, 1694/17951
- Florence Montgomery, Compiler, Monongalia and Tyler Counties Genealogies, 1700/19501
- Fowler Family Papers, 1700/1943, bulk 1830/18601
- George Mason Papers, 1706/18582
- George Mason University Student Government records, 1968/20191