- A. E. Dick Howard papers, 1928/20171
- Baird Family Papers, 1656/1922, bulk 1656/18482
- Benefactions of Francis Nicholson, Esqr. to the Church & Clergy in North America, 1689/17041
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Carter Family Papers, 1667/1862, bulk 1792/18612
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Christian S. Hutter miscellany, 1602/19457
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Dunmore Family Papers (I) [in part photocopies], 1650/18999
- Earl Gregg Swem Papers, 1927/19651
- Edgar E. MacDonald papers, 1933/19931
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199512
- Elizabeth Fairfax cookbook, 1694/17951