- C. Harrison Mann, Jr. map collection, 1579/19611
- Cabell Family Papers, 1693/1913, bulk 1743/18233
- Carol R. Lubin papers, 1960/19812
- Carter Family Papers, 1667/1862, bulk 1792/18616
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/19458
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Dunmore Family Papers (I) [in part photocopies], 1650/18991
- Edgar E. MacDonald papers, 1933/19931
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199510
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Elizabeth Fairfax cookbook, 1694/17953