- A. E. Dick Howard papers, 1928/20171
- Baird Family Papers, 1656/1922, bulk 1656/18483
- Benefactions of Francis Nicholson, Esqr. to the Church & Clergy in North America, 1689/17041
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Carter Family Papers, 1667/1862, bulk 1792/18612
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Christian S. Hutter miscellany, 1602/19457
- Edgar E. MacDonald papers, 1933/19931
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199510
- Elizabeth Fairfax cookbook, 1694/17951
- English Receipt and Home Remedy Manuscript Book, 1665/17041
- Ephemera Collection, 1800/20141
- George Mason University Student Government records, 1968/20191