- Chester McNerney Collection, 1290/19503
- J. Paul Hudson Papers, 1930/19983
- Jack Sandy Anderson, Compiler, Local History Articles and Genealogy Papers, 1600/2011, bulk 2000/20083
- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/19953
- Morley Jeffers Williams Collection, 1602/19673
- Performing arts manuscripts collection, 1475/19843
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/19603
- Tyler Family Papers, Group D, 1939/19513
- Tyler Family Papers, Group G, 1645/19173
- 1828 Catalogue Project digital image collection, 2012/20192
- Armistead-Cocke Papers, 1680/19172
- Bushrod Washington family papers, 1662/18352
- Dunmore Family Papers (I) [in part photocopies], 1650/18992
- English Receipt and Home Remedy Manuscript Book, 1665/17042
- George Washington collection, 1654/17992