- James Edwin Green, Photographer, Glass Plate Negatives and Other Material, 1900/1925, bulk 1900/19181
- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19761
- Jan Karon papers, 1918/2018, bulk 1964/20181
- John D. Hoblitzell, Jr. (1912-1962), Politician, Papers, 1956/19621
- Latin Exercise Book, 1672/17211
- Naval Account Book, 1660/17111
- Ollen Lawrence Burnette, Jr. papers, 1815/20141
- Performing arts manuscripts collection, 1475/19841
- Richard J. DeMartino papers, 1910/19651
- Richard Lee Morton papers, 1756/2006, bulk 1930/19691
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Saint Andrew's Society collection, 1861/19952
- Samuel H. Yonge papers, 1890/19351
- Sheet Music Collection, 1827/19742
- Thomas G. and Louise Rowe Pullen Collection, 1655/17914