- Tyler Family Papers, Group D, 1939/19513
- Tyler Family Papers, Group G, 1645/19173
- Arnold Collins-Thomas Hoare Contract, 16652
- Blow Family Papers, 1613/1960, bulk 1770/18752
- Bushrod Washington family papers, 1662/18352
- Cambridge University Charters, 1575/16692
- Chester McNerney Collection, 1290/19502
- English Receipt and Home Remedy Manuscript Book, 1665/17042
- George Washington collection, 1654/17992
- Hill Family Genealogy, 1700/1999, bulk 1980/19992
- Historic Map and Government Documents Collection, 1630/19782
- Historic manuscript collection, 1601/19332
- J. Paul Hudson Papers, 1930/19982
- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19762
- Morley Jeffers Williams Collection, 1602/19672