- Wade Hampton Frost papers, 1880/19843
- 1828 Catalogue Project digital image collection, 2012/20192
- Blow Family Papers, 1613/1960, bulk 1770/18752
- Cambridge University Charters, 1575/16692
- Chester McNerney Collection, 1290/19502
- George Washington collection, 1654/17992
- Hill Family Genealogy, 1700/1999, bulk 1980/19992
- Historic Map and Government Documents Collection, 1630/19782
- Historic manuscript collection, 1601/19332
- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19762
- Morley Jeffers Williams Collection, 1602/19672
- Naval Account Book, 1660/17112
- Saint Andrew's Society collection, 1861/19952
- Sheet Music Collection, 1827/19742
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19322