- Baylor Family Papers
1653-19151
- Berkeley Family Papers
1536-present1
- English and American legal documents, 1559/18471
- George Washington collection, 1654/17991
- Henkel Family Papers
1791-18851
- Henry Rose Carter papers, 1775/19471
- Latane Family Papers
1650-18981
- Lee Nicholson Papers, 1827/19386
- Manuscripts Artifact Collection, 1800/20101
- Morton Genealogy Collection, 1830/19783
- Papers of the Low Moor Iron Company
1873-19271
- Southall Papers, 1807/19041
- Thruston family commonplace book, 1604/19251
- Tyler Family Papers, Group D, 1939/19512
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19321