- Shenandoah County Historical Society Collection, 1147/20001
- Staffordiensis Comitatus (Reproduction), 16481
- Stanford Family Legal Papers, 1639/17201
- Surria Vernacule Surrey (Reproduction), 16481
- Suthsexia Vernacule Sussex (Reproduction), 16481
- The Thirty Fifth State, Manuscript and Galley, 1609/19601
- Thruston family commonplace book, 1604/19251
- Tyler Family Papers, Group D, 1939/19512
- Tyler Family Papers, Group G, 1645/19173
- Virginia Cities Collection, 1663/19803
- Virginia Counties Collection, 1600/2000, bulk 1730/18906
- Virginia Records, 1623/19211
- Virginia Records, 1632/19331
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19322
- W. Jett Lauck papers, 1900/19522