- Lee Nicholson Papers, 1827/19384
- Tyler Family Papers, Group D, 1939/19512
- Wade Hampton Frost papers, 1880/19842
- Berkeley Family Papers
1536-present1
- Henkel Family Papers
1791-18851
- Henry Rose Carter papers, 1775/19471
- Historic Map and Government Documents Collection, 1630/19781
- Historic Maps of Europe, 1572/18451
- Jerdone Family papers, 1753/18901
- Manuscripts Artifact Collection, 1800/20101
- Morton Genealogy Collection, 1830/19781
- Papers of the Low Moor Iron Company
1873-19271
- Thruston family commonplace book, 1604/19251
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19321