- Papers of the Low Moor Iron Company
1873-19271
- Paul Stevens map collection, 1541/17782
- Performing arts manuscripts collection, 1475/19843
- Raleigh (Ralegh) and Carew family correspondence, 1500/16521
- Richard G. Joynt Collection of British Manuscripts, 1593/20151
- Richard J. DeMartino papers, 1910/19651
- Richard Lee Morton papers, 1756/2006, bulk 1930/19691
- Saint Andrew's Society collection, 1861/19952
- Samuel H. Yonge papers, 1890/19351
- Sheet Music Collection, 1827/19742
- The Thirty Fifth State, Manuscript and Galley, 1609/19601
- Thruston family commonplace book, 1604/19251
- Tyler Family Papers, Group D, 1939/19511
- Tyler Family Papers, Group E, 1880/1951, bulk 1880/19351
- Virginia Cities Collection, 1663/19801