- Richard G. Joynt Collection of British Manuscripts, 1593/20151
- Richard J. DeMartino papers, 1910/19651
- Richard Lee Morton papers, 1756/2006, bulk 1930/19691
- Saint Andrew's Society collection, 1861/19952
- Samuel H. Yonge papers, 1890/19351
- Sheet Music Collection, 1827/19742
- Shenandoah County Historical Society Collection, 1147/20001
- The Thirty Fifth State, Manuscript and Galley, 1609/19601
- Thruston family commonplace book, 1604/19251
- Tyler Family Papers, Group D, 1939/19514
- Tyler Family Papers, Group E, 1880/1951, bulk 1880/19351
- Virginia Counties Collection, 1600/2000, bulk 1730/18901
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19322
- W. Jett Lauck papers, 1900/19522
- Wade Hampton Frost papers, 1880/19842