- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19762
- Jan Karon papers, 1918/2018, bulk 1964/20181
- John D. Hoblitzell, Jr. (1912-1962), Politician, Papers, 1956/19621
- John W. Warner papers, 1967/2009, bulk 1967/20081
- Manuscripts Artifact Collection, 1800/20101
- Margaret Forbes Brand, Compiler, Genealogies, 1500/19651
- Mining Industry, 1000/20001
- Ollen Lawrence Burnette, Jr. papers, 1815/20141
- Papers of the Low Moor Iron Company
1873-19271
- Paul Stevens map collection, 1541/17781
- Performing arts manuscripts collection, 1475/19842
- Raleigh (Ralegh) and Carew family correspondence, 1500/16521
- Richard J. DeMartino papers, 1910/19651
- Richard Lee Morton papers, 1756/2006, bulk 1930/19691
- Saint Andrew's Society collection, 1861/19952