- Chisholm Foundation collection on Frank Gardiner Wisner, 1909/19971
- Clarence B. Pearce papers, 1916/19201
- Clay family memorabilia, 1892/19251
- Coleman, Bromm, Kirschmann family papers, 1861/20181
- Collection of Battle of Rio Hill papers, 19921
- Cultural Alliance of Greater Hampton Roads Records, 1972/20181
- Cumming Family Papers, 1818/19921
- E. Barrett Prettyman Jr. papers, 1944/1989, bulk 1953/19551
- Earl Warren papers, 1951/19741
- Earle K. Shawe papers, 1938/20031
- Edward Henderson Deets Jr. memorabilia, 1943/20041
- Edward O. McCue papers, 1967/19831
- Eugene Edward Chiles papers, 1915/19221
- Ewing family memorabilia, 1892/19821
- Food and Drug Administration photographs, 19101