- Francis H. Fife papers, 1785/2015, bulk 1940/20151
- Frank W. McCulloch papers, 1960/19981
- George Washington Lewis papers, 1805/19661
- George Wilson and Elizabeth Dent Wilson family photos and memorabilia, 1870/19691
- Jack R. Levien papers, 1960/19991
- Jan Karon papers, 1918/2018, bulk 1964/20181
- Jefferson Society records, 1825/20181
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18651
- Marion K. Kellogg papers, 1960/19721
- Monrad G. Paulsen papers, 1960/19791
- Mortimer M. Caplin papers and memorabilia, 1930/20141
- Oscar Ogg papers, 1936/19671
- Peter L. Paull photographs and programs, 1949/19641
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/197414
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771