- Albert R. Gallatin papers, 1795/18281
- Anna Maria Hickman Otis Mead Chalmers family papers, 1821/18971
- Fernande Gontier papers, 1787/20051
- Francis H. Fife papers, 1785/2015, bulk 1940/20151
- George Washington Lewis papers, 1805/19661
- Goss family papers, 1820/2014, bulk 1820/19301
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18651
- Laine family papers, 1772/19611
- Nineteenth-century legal manuscripts, 1820/18591
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19742
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- Somerville family papers, 1821/20131
- William Allen Butler family papers (and related Terry, Collins families), 1808/19591