- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19742
- Ann Norvell Otey Scott Papers, 1920/19481
- Anne H. Cutler Papers, 1930/2013, bulk 1954/20001
- Bowman Family Papers, 1765/19981
- Chester McNerney Collection, 1290/19501
- Gordon M. Buck papers, 1881/1956, bulk 1910/19401
- James L. Skerritt papers, 1910/1978, bulk 1935/19741
- John Ritchie III papers, 1925/19881
- John T. Harris papers, 1771/1937, bulk 1850/19001
- Manley Family papers, 1707/19531
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Patricia Turner Ritchie collection on Brocks Gap, 1750/19901
- Virginia Counties Collection, 1600/2000, bulk 1730/18901