- Baer Family Papers, 1744/19291
- Bowman Family Papers, 1765/19981
- Chester McNerney Collection, 1290/19501
- George Washington Custis Lee papers, 1875/19131
- Gordon M. Buck papers, 1881/1956, bulk 1910/19401
- J. M. Shugar and A. W. Vaisey papers, 1832/19141
- John T. Harris papers, 1771/1937, bulk 1850/19001
- Manley Family papers, 1707/19531
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Matthew Whaley School Collection, 1850/2012, bulk 1880/19601
- McCown Family Papers, 1811/19171
- Monroe County (W. Va.) Court Records and Miscellaneous Papers, 1751/19271
- Moyers Family Letters, 1874/19061
- Patricia Turner Ritchie collection on Brocks Gap, 1750/19901
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19742