- "Hokie High Life" Beer Bottle, 19991
- Alfred C. Payne Collection, 1917/20031
- American Work Horse Museum Collection, 1971/19991
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Antoine Gaujot and Julien E. Gaujot Papers, 1840/19991
- Black Women at Virginia Tech Oral History Project Records, 1967/2000, bulk 1994/20001
- Charles Goodsell Collection, 1982/20011
- College of Agriculture and Life Sciences (CALS) Collection, 1900/20011
- Curtis W. Roane History of Plant Pathology in Virginia and Biographies of Plant Pathologists Papers, 1993/19991
- Dean Carter Papers, 1950/2003, bulk 1964/19821
- Doris Zallen Papers, 1952/20161
- Dr. Richard Zallen Papers, 1940/20071
- Elizabeth Fine Papers, 1983/20121
- G. Preston Frazer Collection, 1939/20031
- George Grigg and John Carnochan Papers, 1969/20151