- Lawrence Washington collection of Washington family papers, 1787/19321
- Log Books of the Steamboat "Sonoma", 18841
- Lyman Stedman, Farmer and Politician, Diary, 1880/18851
- Maria Schwald, Diary Regarding Cruise Along the Ohio River, 1935/19521
- Miles Dahmer Papers, 1791/19131
- Nathan Hanes (1821-1899) Papers, 1845/19001
- Ohio River Sheet Music and Other Material, 1845/19861
- Ohio River Shipping Accounts, 1883/18841
- Pauline Morehead Ash, Collector, Papers, 1855/19471
- Pittenger Family Letters, 1841/18751
- R.H. Hendershot Shipping Bills, 1850/18541
- Robert E. Lee Keadle, Monroe County, Diary, 1886/18911
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/19601
- Roy Bird Cook, Collector, Papers regarding the Civil War in Southern West Virginia, 1844/1938, bulk 1861/18671
- Roy Thistle, Collector, Scrapbook regarding Ohio River History, 1855/19341