- Bray Papers, 1730/18171
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Cuttbert Bullitt letter, 17961
- Jerdone Family papers, 1753/18901
- McGavock Family Papers, 1760/18881
- Oscar Shewmake Autograph Collection, 1766/18131
- Patrick Henry Papers, 1778/19271
- Perrin Family Bibles, 1751/1838, bulk 1751/18381
- Powell Family Papers, Hepburn Addition, 1775/18701
- Richard Blow Papers, 1772/18721
- Robert Andrews Papers, 1779/1796, bulk 1781/17961
- William K. Perrin Papers, 1732/1902, bulk 1820/18581
- William Selden Papers, 1772/17991