- Collection of Spanish Language Manuscripts, 1551/18581
- Georgia Collection, 1806/18721
- Gibson Lamb Cranmer Papers regarding Statehood and Other Material, 1787/1895, bulk 1822/18811
- Gideon D. Camden (1805-1891) Papers, 1784/18991
- Gideon D. Camden (1805-1891) Papers, 1816/18921
- Henry Ruffner collection, 1815/18671
- John S. Barret Journal, 1814/18501
- John White Papers, 1757/18431
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19491
- Randolph Family papers, 1796/18821
- Rockbridge County records, 1778/19121
- Schoenbrun Collection of Virginia Historical Manuscripts, 1813/18951
- South Carolina Papers, 1795/18671
- William and Anne Fleming Family papers, 1754/20001