- Collection of Spanish Language Manuscripts, 1551/18581
- George Washington collection, 1654/17991
- Gibson Lamb Cranmer Papers regarding Statehood and Other Material, 1787/1895, bulk 1822/18811
- Gideon D. Camden (1805-1891) Papers, 1784/18991
- Historic manuscript collection, 1601/19331
- John White Papers, 1757/18431
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19491
- Peter family papers, 1722/19321
- Randolph Family papers, 1796/18821
- Rockbridge County records, 1778/19121
- South Carolina Papers, 1795/18671
- William and Anne Fleming Family papers, 1754/20001