- A. Willis Robertson Papers, 1921/1988, bulk 1946/19661
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19791
- Armand J. Galfo Papers, 1940/2008, bulk 1958/19951
- B. Floyd Flickinger Papers, 1927/19501
- Blake W. Corson, Jr., Papers, 1861/1984, bulk 1934/19791
- Board of Visitors records, 1757/20231
- Career Center Records, 1939/2001, bulk 1950/19851
- Charles J. Duke, Jr. Papers, 1919/19581
- Chesapeake Western Railway Company Records, 1916/19821
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- College Papers Collection, 1880/19991
- College Rules Collection, 1849/19551
- College of William and Mary Audit Reports Collection, 1934/19881
- Department of Fine Arts records, 1930/19981
- Department of Home Economics Records, 1921/19711