- A. Willis Robertson Papers, 1921/1988, bulk 1946/19661
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19791
- B. Floyd Flickinger Papers, 1927/19501
- Board of Visitors records, 1757/20231
- Charles J. Duke, Jr. Papers, 1919/19581
- Chesapeake Western Railway Company Records, 1916/19821
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- College Papers Collection, 1880/19991
- College Rules Collection, 1849/19551
- Department of Fine Arts records, 1930/19981
- Department of Home Economics Records, 1921/19711
- E. Lockert Bemiss Papers, 1893/19551
- Earl Gregg Swem Library records, 1920/20241
- Earl Gregg Swem Papers, 1927/19651
- Eastern State Hospital Records, 1862/1957, bulk 1862/18681