- Henry Waring Latane Lewis family papers, 1826/18931
- Historic manuscript collection, 1601/19331
- Jabez and Joseph M. Gravely Papers, 1796/18611
- John Garland Pollard Papers, 1683/1968, bulk 1856/19371
- John Henry Tabb Papers, 1826/18561
- John L. Heatwole Collection of Shenandoah Valley History, 1802/19011
- John T. L. Preston papers, 1806/18891
- John Tyler, Jr. Papers, 1800/19281
- Lexington Arsenal and Virginia Militia records, 1702/18391
- Liskey Collection of Heavner Family Papers, 1788/19671
- Maritime Bills of Lading, 1830/18691
- Mary and Hannah Gibbons Papers, 1743/18901
- McGavock Family Papers, 1760/18881
- Mongle-Hughes Papers, 1832/19161
- Nelson County Va. Sheriff's Receipt Book, 1811/1837, bulk 1811/18321