- Blow Family Papers, 1613/1960, bulk 1770/18751
- Borland Family Papers, 1771/19401
- Bucktrout-Braithwaite Papers, 1780/1996, bulk 1890/18991
- Campbell Family Papers, 1726/19201
- Carpenter Papers, 1765/19221
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles Carroll papers, 1770/18261
- Christopher Tompkins Papers, 1778/18381
- Clarence P. Jones, Jr. Papers, 1773/1915, bulk 1809/18211
- Connecticut Silk Industry Collection, 1786/17921
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Frederick Herman Collection, 1788/19731
- George Washington collection, 1654/17991
- Godwin-Riddick Family Papers, 1783/18861
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301