- Calendars Collection, 1910/20131
- Campaigns and Elections Collection, 1816/1972, bulk 19321
- Career Center Records, 1939/2001, bulk 1950/19851
- Carl R. Dolmetsch Papers, 1751/19901
- Carlton Casey Papers, 1894/19991
- Carter Lowance Papers, 1860/1993, bulk 1942/19881
- Center for Student Diversity Records, 1975/20131
- Charles Brown Papers, 1792/18881
- Charles J. Guiteau Papers, 1877/18811
- Christopher Bram Papers, 1968/2014, bulk 1975/20001
- Christopher Newport College Records, 1959/19771
- Civil War Collection, 1856/19381
- Cotesworth P. Lewis Papers, 1938/19951
- Curtis West Harris and Ruth Jones Harris Papers, 1950/20121