- Randall S. Hawthorne Papers, 1935/2014, bulk 1980/20001
- Rene A. Henry papers, 1953/20171
- Rev. Samuel Huntting Sayre, Jr. Papers, 1874/1989, bulk 1920/19601
- Reves Center for International Studies Records, 1926, bulk 19891
- Robert Edward Bruce Stewart, Jr. Papers, 1924-1927, 1924/19271
- Robert Stewart Papers, 1954/1988, bulk 1960/198012
- S. Louise Seymour Scrapbooks, 1939/19431
- School of Education Records, 1930/20081
- Scrapbook of Opera, Concert, and Play Programs, 1887/18911
- Scrapbook of Theatre Programs, 1924/19361
- Sinfonicron Light Opera Company records, 19651
- Sons of the American Revolution Virginia Society Williamsburg Chapter records, 1969/20231
- South Asian Student Association records, 1991/20091
- Southern University Conference Records, 1976, 1964/19771
- Stephen P. Middleton Letter Book and Diary, 1880/18931